|
KMID : 0376419840080020353
|
|
Chonbuk University Medical Journal
1984 Volume.8 No. 2 p.353 ~ p.360
|
|
|
Immunocytochemical Identification of Factor Ⅷ/von Willebrand factor in Endothelial Cells of Hyperplastic Vessels and Vascular Tumors
|
|
|
|
|
Abstract
|
|
|
The clinical significances of factor VIII/von Willebrand factor antigen(FVIII/vWF-Ag) in various vascular lesions including vascular tumors atd inflammatory reactive proliferation was investigated. FVIII/vWF-Ag was detected in tissues of hyperplastic vessels in peptic ulcer, capillary hemangioma, cavernous heman_gicma, hernargioer dothelicma, and hemangiopericytema by means of peroxidase-antiperoxidase(PAP) method.
The results were as follows.
1. Endothelial cells of hyperplastic vessels in peptic ulcer showed strong positive reaction.
2. Neoplastic endothelial cells in capillary hemangicma showed moderate to strong positive reaction, but the mesenchymal cells didn´t show positive reaction.
3. Endothelial cells of dilated vessels in cavernous hemangioma and thrombus in the vascular lumen showed strong positive reaction, but the markedly attenuated cells and necrotic cells showed negative reaction.
4. Neoplastic cells in hemargioerdothelicrra showed weak to mcderate positive reaction.
5. Neoplastic cells in hemangiopericytoma showed negative reaction According to these results, FVIII/vWF-Ag was limited in the endothelial cells. And the degree of positivity depends on the degree of cellular differentiation. So the more differentiated cells show the stronger reaction.
Detection of FVIII/vWF-Ag by PAP methcd may be helpful in diegnosis of vascular endothelial lesions.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|